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Ulcers and Gastroprotective
Blessed Sunnah Black Seed

Nigella sativa seeds was effective in reducing the ulcer index

Ulcers and Gastroprotective

An animal study suggested that the aqueous extract of Nigella sativa seeds was effective in reducing the ulcer index (induced by aspirin) by about 36%. Moreover, the treatment reduced the peptic activity and acid production. Another study found that the administration of black seed oil for 2 weeks increased gastric mucin and glutathione content, and reduced histamine content. This is in line with earlier studies that have suggested a cytoprotective action of black seed oil, and lends some credence to the folkloric use of the oil as an antiulcer agent. A different study discovered a single oral dose of black seed could partly reduce the ulcer index and promote healing of gastric lesions induced by acute intake of alcohol. Additionally, black seed significantly decreased the gastric MDA content while it increased the gastric level of glutathione compared to alcohol. The gastric activities of both antioxidant enzymes superoxide dismutase (SOD) and glutathione-S-transferase (GST) were markedly elevated following administration of black seed. Likewise, thymoquinone protected against the ulcerating effect of alcohol and mitigated most of the biochemical adverse effects induced by alcohol in gastric mucosa, but to a lesser extent than whole black seed. Researchers also hypothesized that thymoquinone’s antihistaminic effect could play a role in preventing gastric injury as an antihistaminic effect has been shown to be an important preventive mechanism against gastric injury. Given its safety profile, don’t be surprised if thymoquinone will be a choice of treatment for gastric ulcers in the near future.

Akhtar AH, Ahmad KD, Gilani SN, et al. Antiulcer effects of aqueous extracts of Nigella sativa and Pongamia pinnata in rats. Fitoterapia 1996; 38: 195–199.

El-Abhar HS, Abdallah DM, Saleh S. Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats. J Ethnopharmacol. 2003 Feb;84(2-3):251-8. El-Dakhakhny M, Barakat M, El-Halim MA, et al. Effects of Nigella sativa oil on gastric secretion and ethanol induced ulcer in rats. J Ethnopharmacol. 2000 Sep;72(1-2):299-304.

El-Kadi A, Kandil O, Tabuni AM. Nigella sativa cell-mediated immunity. Arch AIDS Res. 1987; 1: 232–233.

Kahraman A, Erkasap N, Köken T, et al. The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions. Toxicology. 2003 Feb 1;183(1-3):133-42.

Kanter M, Coskun O, Uysal H. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, thymoquinone on ethanol-induced gastric mucosal damage. Arch Toxicol. 2006 Apr;80(4):217-24.

Kanter M, Demir H, Karakaya C, et al. Gastroprotective activity of Nigella sativa L oil and its constituent,thymoquinone against acute alcohol-induced gastric mucosal injury in rats. World J Gastroenterol. 2005 Nov 14;11(42):6662-6.