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Blessed Sunnah Black Seed

Black seed can be used as an antihypertensive agent


It has been suggested that black seed oil could be effectively used to treat hypertension. This lends credibility to the folkloric use of the oil as an antihypertensive agent. The methanol soluble portion of the oil showed inhibitory effects on arachidonic acid induced platelet aggregation and blood coagulation. What's more, several compounds displayed anticoagulation effects more potent than aspirin, which is a common therapeutic agent for thrombosis. A French study found that the dichloromethane extract of black seed shows strong diuretic and antihypertensive actions. In fact, the authors suggested that the diuretic action of black seed might be, at least partially, responsible for its antihypertensive action related to its volatile oils.

Another study reported that the oral treatment of rats with black seed oil decreased serum cholesterol, triglyceride and glucose levels, and leucocyte and platelet counts by about 15–35%, compared to control values. These results indicate a possible beneficial effect of the oil in hyperglycaemia and hyperlipidema, and probably as an adjunct to the treatment of certain types of anaemia. Several extracts of Nigella sativa significantly reduced plasma triglycerides while increasing HDL-cholesterol. Besides, one study reported that the volatile oil of Nigella sativa was as efficient as the cholesterol-reducing drug simvastatin. As a matter of fact, a study involving nine students found that two capsules of 500 mg of black seed oil twice daily for two weeks was able to reduce blood levels of both glucose and cholesterol.

Moreover, scientific evidence also indicates that black seed oil and thymoquinone are effective in reducing homocysteine levels. Evidence using animal models suggests that homocysteine causes direct oxidant injury to the vasculature, impairs the vasodilator and anticoagulation function of nitrous oxide, stimulates smooth muscle proliferation, interferes with clotting factors and increases oxidative stress. Black seed oil may offer an alternative for homcysteine reduction to those people that do not respond to folic acid, vitamins B12 and or B6.

Bamosa AO, Ali BA, Sowayan SA. Effect of oral ingestion of Nigella sativa seeds on some blood parameters. Saudi Pharm J. 1997;5:126–129.

el Tahir KE, Ashour MM, al-Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa)in rats: elucidation of the mechanism of action. Gen Pharmacol. 1993 Sep;24(5):1123-31.

Enomoto S, Asano R, Iwahori Y, et al. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol Pharm Bull. 2001 Mar;24(3):307-10.

Labhal A, Settaf A, Bennani N, et al. Action anti-obésité et hypocholestérolémiante de Nigella sativa chez le rat des sables. 1997 Caducée 27:26–28.

Le PM, Benhaddou-Andaloussi A, Elimadi A, et al. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J Ethnopharmacol. 2004 Oct;94(2-3):251-9.

Settaf A, Berrada Y, Haddad PS, et al. Volatile oil of Nigella sativa lowers plasma lipids and insulin in obese hyperlipidemic sand rats (Psammomys obesus). 2000 6th International Congress on Ethnopharmacology:P2A/36.

Stamler JS, Slivka A. Biological chemistry of thiols in the vasculature and in vascular-related disease. Nutr Rev. 1996 Jan;54(1 Pt 1):1-30.

Tsai JC, Perrella MA, Yoshizumi M, et al. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6369-73.

van Guldener C, Stehouwer CD. Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction. Semin Thromb Hemost. 2000;26(3):281-9.

Zaoui A, Cherrah Y, Mahassini N, et al. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine. 2002 Jan;9(1):69-74.

Zaoui A, Cherrah Y, Lacaille-Dubois MA, et al. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat] [Article in French] Therapie. 2000 May-Jun;55(3):379-82.